Multiparametric High Field PET / MRI


The 9.4 Tesla (Bruker Biospin 94/30) preclinical MRI system with a gradient bore size of 30 cm allows multiparametric functional imaging of small animals (sizes from mice up to small piglets). With an additional PET-Insert® (Bruker) simultaneous PET/ MRI measurements can be performed. By merging the resulting data this hybrid imaging technique provides supplementary information on the functional and molecular level of the examined tissue. A MRI CryoProbe® (Bruker) which increases sensitivity of in-vivo probes by factors of 2.5 to 5.3 compared to standard room temperature RF-coils further improves the performance of the system. The fusion with our SPECT/ CT system (see uSPECT /CT) makes the system unique and allows novel molecular insights into any given disease by fusing MRI as well as SPECT data.

Ressources

  • BGA 12S gradient system (mouse, rat, …)
  • BGA 20S gradient system (rabbit, piglet, …)
  • motor driven automatic positioning system
  • monitoring unit for physiological functions
  • various sizes of 4 channel array coils for heart, spine, head applications
  • different sizes of transmitter/receiver quadrature resonators for body applications
  • 1H, 19F, 31P, 23Na and 13C coils for spectroscopy
  • MRI CryoProbe® with MRI cryocooler, unique cryo coil working at temperatures of 20 to 35 Kelvin (-253.15 to -238.15 degrees Celsius)
  • fusion with PET / SPECT data

Operators




 




Applications

  • high-resolution 3D imaging (Phenotyping) with various contrasts (T1,T2,T2*, diffusion, magnetization transfer…)
  • cardiac/ oncologic/ brain/ musculo-skelettal multiparametric functional, morphological and molecular imaging
  • biomarker imaging
  • MRI cell labeling and tracking
  • 1H, 19F, 31P, 23Na and 13C spectroscopy
  • Molecular PET / MRI multiparametric functional and molecular imaging
  • Development of unique contrast agents and tracers (for PET, SPECT, MRI and optical imaging)